A Cluster to Remember Cell Biology Diagrams Many proteins that carry out important functions during the cell cycle display a cyclic expression pattern that is often regulated on the transcriptional level (13, 14).Because it has been shown that cell-cycle gene expression serves as a tumor signature (), extensive efforts have been devoted to identify periodically expressed genes across the cell cycle using microarray platforms (4, 16-20). The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding of the roles and functions of the E2F family has made enormous progress, with each discovery new questions arise.
Significance of the periodic transcription program. (a) Genes are expressed only during the cell-cycle phase needed.Genes required for DNA replication are expressed during S phase. (b) The temporal order of gene expression may aid in the construction of a protein complex only needed once per cycle.(c) While protein levels of cell-cycle regulators may remain constant, posttranslational This work has revealed many new insights into how transcription of different G1-S cell cycle genes is restricted to G1 and how this is regulated by DNA replication checkpoint protein kinases as part of the checkpoint transcriptional response. Landman A, Futcher B. The G1 cyclin Cln3 promotes cell cycle entry via the transcription factor Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB):E2F and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin-dependent kinase (CDK) phosphorylation of RB and DREAM allows for the expression of two gene sets. The first set of genes, with peak expression in G1/S, is activated by E2F transcription factors (TFs) and is required for
Transcriptional regulation and function during the human cell cycle ... Biology Diagrams
A list of 102 cell cycle genes was generated by combining 68 key cell cycle genes reported by ref. 74 with a manually curated list of 34 genes. The MYC target gene list was previously reported by Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as differentiation and development, and of the cellular response to external perturbation through signaling pathways. In this review we focus on the role of TFs as a link between signaling pathways and gene regulati โฆ Classical regulators include the transcription factors E2F1 and FOXM1 that are required for the temporal control of gene expression in G1-S and G2-M stages of cell cycle, respectively 4,19,20,21
Among 3028 cell cycle associated genes, 2125 genes are validated targets of 424 microRNAs; CDKN1A is a target of 46 miRNAs and miR-335 targets 301 genes. About 100 transcription factors had binding sites at potential promoter regions of 2722 genes and 329 microRNAs that target cell cycle associated genes. We presented the largest numbers of
